DNA-PROBIO
A patent-pending blend of protease enzymes, five probiotics species, and a prebiotic designed to promote optimal protein digestion, a healthy gut microbiome, and enhanced absorption of Branched Chain (BCAAs), Essential and Non-Essential Amino Acids.
Designed to support protein digestion and absorption of amino acids and postbiotics DNA-Probio is a patent-pending blend of protease enzymes, five probiotics species, and a prebiotic shown in clinical trials to promote optimal protein digestion, a healthy gut microbiome, and enhanced absorption of branched chain amino acids (BCAAs), essential and non-essential amino acids. Clinical studies show DNA-Probio (DigeSEB SportTM) promotes the production and bioavailability of postbiotics L-citrulline, L-alanine, L-ornithine, Anserine, and the neurotransmitter Gamma-aminobutyric acid (GABA).
Some probiotics don’t survive the harsh acidic conditions of the stomach. Many don’t reach the gut, limiting their efficacy. DNA-PROBIO Capsules use a patented slow release capsule (DRcaps®). The innovative DRcaps® capsule dissolves after an extended time period (approx 40 minutes), protecting ingredients from degradation in the stomach and delivering them into the small intestine where they are most effective.
Probiotics, Enzymes & Protein Absorption
For athletes and health enthusiasts alike, undigested protein can lead to an unhealthy gut microbiome and symptoms such as bloating, gas, and even kidney and liver problems. DNA-Probio promotes microflora diversity and balance, helping to prevent the negative effects of protein indigestion.
DNA-ProBio increases amino acid release by up to 51%, showing enhanced protein digestion. Protein is an essential source of energy. It is comprised of long chains of amino acids and is involved in DNA replication, cell division, metabolism, and maintaining the body’s structure and function. For the body to utilize this energy, the protein must be broken down into smaller, more absorbable components. Undigested protein can cause various health issues, including bloating, gas and inflammation.
Science and research
Randomized, double blind, placebo-controlled, crossover clinical trials evaluated the effect of DNA-Probio when taken with whey or pea protein on amino acid absorption and the gut microbiome. Results of these two studies found that DNA-Probio improved protein digestion, increased essential amino acid and branched chain amino acid (BCAA) release and absorption, and supported the maintenance of a health gut microbiome.
The clinical trials also showed that DNA-Probio supports increased production of postbiotics such as GABA, shown to regulate skin health, stress, anxiety and depression, physical endurance, healthy ageing, inflammation and cardiac health.
Postbiotics released when DNA-Probio is taken with protein include:
Gamma-aminobutyric acid (GABA). A non-protein inhibitory neurotransmitter of the central nervous system that modulates synaptic transmission, promotes neuronal development and relaxation, and prevents sleeplessness and depression. Low GABA levels lead to anxiety, depression, insomnia, mood disorders, seizures and epilepsy. GABA also shows cardio-protection, antioxidant, pain relieving and anti-diabetic effects.
Beta-Alanine. Beta-Alanine promotes athletic performance, cognitive function during stressful conditions, and resiliency to stress. Beta-Alanine also promotes cellular oxygen consumption and the expression of cellular proteins associated with improved oxidative metabolism.
L-Citrulline. A neutral, non-proteinogenic alpha-amino acid, and an important component of the urea cycle in the kidney and liver which removes ammonia from the blood. L-Citrulline promotes healthy blood pressure, regulation of innate and adaptive immunity, functional antioxidant management, muscle and metabolic health, cardiac function, age-related muscle damage, endothelial vasodilator, and anti-diabetic functions.
L-Ornithine. A non-proteinogenic amino acid shown to promote stress reduction, sleep, energy levels, mental focus, skin health, the synthesis and production of collagen, muscle growth and basal metabolism.
Anserine. A histidine containing dipeptide that acts as a biochemical buffer, chelator, antioxidant, anti-inflammatory, and anti-glycation agent. Anserine promotes relief from stress, anxiety and fatigue, post-partum lactation, exercise performance, healthy blood sugar and pressure levels, immune health, healthy ageing, immune health and wound healing.
The largest number of probiotics live in the colon, but billions also live in the mouth, oral cavity, nasal cavity, the esophagus, around the gums, in the pockets of our pleural cavity (surrounding our lungs). They dwell within our stomach, our intestines, within the vagina, around the rectum. within joints, under the armpits, under the toenails, between the toes, urinary tract, inside our urinary tract and many other places!
Intestinal microflora balance can be disrupted by factors such as antibiotics, stress, alcohol, among others, which can lead to diarrhea, cramping, bloating and overgrowth of opportunistic organisms. Supplemental DNA-PROBIO promotes a healthy gut microbiome.
Ideal for athletes, DNA-Probio promotes BCAA and essential amino acid release and absorption, and a healthy gut microbiome. The benefits continue post-workout as it may support muscle repair and recovery, relief from anxiety, sleeplessness and depression.
Each Slow release 600mg DNA-PROBIO vegetable capsule contains 600mg of DigeSEB Sport™. Sold under licence from Speciality Enzymes and Probiotics, CA, USA. Contains no fillers or preservatives
Manufacturing
The manufacturing facilities are GMP-certified and include: clean room production systems; environmental controls to monitor temperature and humidity; food-safe wall panels and epoxy floors; refrigerated raw material storage; and much more as part of a complete quality control system.
Rigorous Testing
All products are tested in the in-house ISO-17025 certified laboratories in California. They test at every step of the process, from raw materials to finished goods. In addition to enzyme assays and probiotic counts, the testing capabilities include identity, heavy metals, and microbiological testing.
A Natural Product Number (NPN) is granted by Health Canada after a rigorous regulatory review of scientific evidence to provide consumer reassurance that the natural product is safe, effective, and high quality. Health Canada also approves specific health claims for product labeling and advertising. Health Canada has approved the following claims for SEBiotic®, SEBtilisTM and SEBclausiiTM.
Probiotics in DNA-Probio
Bacillus coagulans LBSC is a powerful spore-forming, shelf-stable and room temperature stable probiotic.
It promotes intestinal homeostasis, promotes recovery from diarrhea and constipation, and supports antimicrobial compound production and competitive pathogen exclusion. It also promotes intestinal barrier function and immune modulation. Shows promising results on inflammatory bowel conditions.
SEBtilisTM (Bacillus subtilis PLSSC)
A potent spore-forming, shelf-stable probiotic shown to support immune health and promote a healthy gut microbiome
SEBclausiiTM (Bacillus clausii 088AE)
A unique spore-forming, shelf-stable probiotic that exhibits antibiotic-resistant properties and supports a health microflora balance and immune function. Helps reduce the symptoms related to antibiotic-associated diarrhea.
Helps support the maintenance of digestive health.
Lactobacillus acidophilus
L. acidophilus is a species of beneficial microbial flora and has been proven to play an important role in many pathological and physiological processes. It has been shown to improve CVD (cardio-vascular disease) and lactose intolerance, prevent and treat cancer, regulate immunity, and improve gastrointestinal diseases. Shows promising results for skin health.
Lactiplantibacillus plantarum
L. plantarum has been applied in medical fields for the treatment of various chronic and cardiovascular diseases such as Alzheimer's, Parkinson's, diabetes, obesity, cancer, hypertension, urinogenital complications, liver disorders, etc. (Woo et al., 2014). It promotes healthy microflora balance, gut microbiome and immune modulation, aids in protein absorption, skin health and inflammation management.
By producing bioavailable postbiotics L-citrulline, ß-alanine, L-ornithine, Anserine, and the neurotransmitter Gamma-aminobutyric acid (GABA), DNA-Probio Capsules support;
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Emotional well-being
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Immune health
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Gut health
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Skin health
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Cognitive Health (Stress, Anxiety, and Depression)
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Digestive Health
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Healthy bowel movements 2,7
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Optimal protein absorption
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Healthy microflora balance 3
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Healthy inflammation levels 4
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Recovery from post-viral infection 5,6
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Stimulating tolerance of allergic rhinitis symptoms
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Improved symptoms associated with upper respiratory tract viral infections 4,8,9
DNA-Probio is heat-stable and resistant to stomach acid 3
How probiotics might improve immune function
There are all sorts of things that can throw the balance of “good” and “bad” bacteria in your intestines out of whack. Something as simple as a week-long course of antibiotics can devastate a bacteria colony that’s been thriving in your body for decades. And that, in turn, can give you anything from diarrhea to chronic headaches, skin problems, the sniffles or worse. Some researchers theorize that an imbalance in the gut microbiome could be a cause of irritable bowel syndrome. It’s also been linked to an increase in depression or anxiety, multiple sclerosis flares and chronic kidney disease. While they’re not sure how it happens, all this research points to rebalancing the microbiome as a potential solution. And, in some small studies, using probiotics to do just that has resulted in a decrease of symptoms.
The link between your gut and your immune system
To get how probiotics affect your immune function, you first need to understand the relationship between the gastrointestinal tract and your immune health. In the last few years, scientists at the best research universities in the world have begun to figure out how bacteria in the gut impacts the immune system and your overall wellness. It turns out that much of the immune system is actually in the GI tract. There are cells in the intestines that secrete antibodies into your bloodstream, which help your body fight different illnesses and ailments. It turns out that the immune system is all about balance. If your body fights off too many “bad” cells, it can trigger a negative bodily response that can potentially cause other health complications. However, if it doesn’t fight off enough, you can become seriously ill. Your gut is all about balance, too. This balance is between “good” bacteria and “bad” bacteria, trillions of which reside in your intestines. Some of these bacteria help you digest food, breaking it down into essential nutrients that your body can use as fuel. Other types of bacteria trigger an immune response, which could lead to the release of antibodies that we mentioned earlier. Scientists don’t yet understand exactly how these bacteria work together to keep you healthy, or why certain types of bacteria are more prevalent than others. What they do know is that when the balance is off, people get sick.
References
1. Gupta, A. K., & Maity, C. (2021). Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical
study [CONSORT Compliant]. Medicine, 3, 100.
2. Maity, C., & Gupta, A. K. (2019). A prospective, interventional, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Bacillus coagulans LBSC in the
treatment of acute diarrhea with abdominal discomfort. European Journal of Clinical Pharmacology, 75, 21-31.
3. Maity, C., & Gupta, A. K. (2021). Impact of a gastrointestinal stable probiotic supplement Bacillus coagulans LBSC on human gut microbiome modulation. Journal of Dietary Supplements, 18(6),
577-596.
4. Shah, N., et. al. (2021). Potential of the combination of a systemic enzyme complex and probiotics administration to combat COVID-19: A randomized open label prospective analysis. Advanced
in clinical Toxicology, 6(1).
5. Parate, R., & Shah, N. (2021). Management of post COVID-19 fatigue using systemic enzymes and probiotics- case series. Medicinal Journal of Clinical Trials and Case Studies, 5(2).
6. Rathi, A., Jadhav, S. B., & Shah, N. (2021). A randomized controlled trial of the efficacy of systemic enzymes and probiotics in the resolution of post-COVID fatigue. Medicines, 8(9), 47.
7. Maity, C., & Gupta, A. (2021). Therapeutic efficacy of probiotic Alkalihalobacillus clausii 088AE in antibiotic-associated diarrhea: A randomized controlled trial. Heliyon, e07993.
8. Maity, C., & Gupta, A. (2021). A prospective, interventional, randomized, double-blinded, placebo-controlled clinical study to evaluate the efficacy and safety of Bacillus clausii 088AE as
immunomodulator in acute allergic rhinitis. Mendeley Data, V1, doi: 10.17632/r28yk274z6.
9. Maity, C., & Gupta, A. (2021). A prospective clinical study to evaluate the efficacy and safety of a probiotic combination of Bacillus clausii 088AE, Bacillus coagulans LBSC and Bacillus subtilis
PLSSC as immunomodulators in acute allergic rhinitis. Mendeley Data, V1, doi: 10.17632/dxx7czctmx.1
10. Bagkar, P. et al. (2021). Process and storage stability of Bacillus coagulans LBSC in food matrices and appraisal of calorific restriction. Applied Food Biotechnology, 8(1):57-69.
11. Center for Food Safety and Applied Nutrition Food and Drug Administration. (2020). FDA GRAS Notice Bacillus coagulans LBSC. Retrieved from https://fda.report/media/145555/GRAS-No-
tice-GRN-949-Bacillus-coagulans-w-amendments.pdf
12. Center for Food Safety and Applied Nutrition Food and Drug Administration. (2020). FDA GRAS Notice Bacillus subtilis PLSSC. Retrieved from https://www.fda.gov/media/146998/download
13. Center for Food Safety and Applied Nutrition Food and Drug Administration. (2020). FDA GRAS Notice Bacillus clausii 088AE. Retrieved from https://www.fda.gov/media/151721/download
14. NPN #80121786 SEBiotic® https://health-products.canada.ca/lnhpd-bdpsnh/ info?licence=80121786
15. NPN #80121937 SEBtilisTM https://health-products.canada.ca/lnhpd-bdpsnh/info?licence=80121937
16. NPN #80121938 SEBclausiiTM https://health-products.canada.ca/lnhpd-bdpsnh/info?licence=80121938
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